Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | MMP13 | P45452 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4411701 | 0.81 | HSD17B10 (0.59) | LMNAHTTMMP13SMN1; SMN2ALDH1A1 | |
| SCHEMBL15319936 | 0.81 | ALDH1A1 (0.73) | NPSR1TSHRRECQLLMNANFKB1 | |
| SCHEMBL7082686 | 0.78 | TSHR (0.73) | NPSR1TSHRRECQLLMNAHTT | |
| SCHEMBL29460250 | 0.77 | FES (0.81) | NPSR1RECQLKMT2ASMN1; SMN2PKM | |
| SCHEMBL9130703 | 0.77 | FES (0.81) | NPSR1RECQLKMT2ASMN1; SMN2PKM | |
| SCHEMBL1570163 | 0.77 | ACE2 (0.48) | NPSR1HPGDKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1161997 | 0.77 | NAMPT (0.75) | LMNAHTTUSP2MMP13KMT2A | |
| SCHEMBL1568226 | 0.77 | ALDH1A1 (0.72) | NPSR1TSHRRECQLLMNAHTT | |
| SCHEMBL5783915 | 0.77 | HTT (0.71) | NPSR1TSHRLMNAHTTMMP13 | |
| SCHEMBL10403403 | 0.76 | RECQL (0.72) | NPSR1TSHRRECQLLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |