Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4411608 | 0.92 | PLA2G7 (0.57) | PLA2G7CYP3A4 | |
| SCHEMBL4425737 | 0.91 | PLA2G7 (0.59) | PLA2G7CYP3A4 | |
| SCHEMBL4415976 | 0.89 | PLA2G7 (0.57) | PLA2G7CYP3A4 | |
| SCHEMBL7601075 | 0.89 | PLA2G7 (0.53) | PLA2G7CYP3A4 | |
| SCHEMBL4419222 | 0.88 | PLA2G7 (0.57) | PLA2G7 | |
| SCHEMBL4552007 | 0.87 | PLA2G7 (0.74) | PLA2G7CYP3A4 | |
| SCHEMBL4412340 | 0.87 | PLA2G7 (0.51) | PLA2G7CYP3A4 | |
| SCHEMBL4416174 | 0.87 | PLA2G7 (0.59) | PLA2G7 | |
| SCHEMBL4385379 | 0.86 | PLA2G7 (0.59) | PLA2G7CYP3A4 | |
| SCHEMBL3538336 | 0.85 | PLA2G7 (0.58) | PLA2G7CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| CN-1286822-C | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-11-29 | — | — | CN | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |
| EP-1175408-B1 | PYRIMIDINONE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2004-12-01 | — | — | EP | disclosed |
| EP-1479671-A1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2004-11-24 | — | — | EP | disclosed |
| US-20040167142-A1 | Pyrimidinone compounds | SMITHKLINE BEECHAM P.L.C. | 2004-08-26 | — | — | US | disclosed |
| CN-1358175-A | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2002-07-10 | — | — | CN | disclosed |
| EP-1175408-A1 | PYRIMIDINONE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066567-A1 | PYRIMIDINONE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167142-A1 | Pyrimidinone compounds | LPL, LIPG, PCSK9 | PLA2G7 43/4885CYP3A4 1555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.