Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNOT7 | Q9UIV1 | 7/20 | 0.72 |
| ▸ | PARN | O95453 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | PDE1A | P54750 | 1/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16076166 | 0.88 | LMNA (0.61) | CNOT7PARNSMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL8798601 | 0.86 | CNOT7 (0.76) | CNOT7PARNSMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL13861874 | 0.85 | CNOT7 (0.70) | CNOT7PARNSMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL14327687 | 0.85 | CNOT7 (0.53) | CNOT7PARNSMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL13217674 | 0.80 | ALDH1A1 (0.66) | CNOT7PARNADORA2BLMNAALDH1A1 | |
| SCHEMBL2795748 | 0.78 | POLB (0.75) | CNOT7PARNSMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL2956851 | 0.78 | ALDH1A1 (0.59) | CNOT7PARNADORA2BLMNAALDH1A1 | |
| SCHEMBL1065735 | 0.78 | LMNA (0.59) | CNOT7PARNSMN1; SMN2ADORA2BLMNA | |
| SCHEMBL9386947 | 0.78 | SMN1; SMN2 (0.58) | CNOT7PARNSMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL19036472 | 0.78 | CNOT7 (0.51) | CNOT7PARNSMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786301-B2 | Process for preparing xanthine phosphodiesterase V inhibitors and precursors thereof | SCHERING CORPORATION (US) | 2010-08-31 | — | — | US | disclosed |
| WO-2009144548-A1 | IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2009-12-03 | — | — | WO | disclosed |
| EP-0538332-B1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORP (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5393755-A | Hypotensive agents, enzyme inhibitors | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538332-A1 | POLYCYCLIC GUANINE DERIVATIVES. | SCHERING CORP (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1991019717-A1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |