Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNOT7 | Q9UIV1 | 7/20 | 0.70 |
| ▸ | PARN | O95453 | 1/20 | 0.70 |
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798601 | 0.91 | CNOT7 (0.76) | CNOT7PARNBRD4POLBHIF1A | |
| SCHEMBL2984842 | 0.87 | CNOT7 (0.54) | CNOT7PARNBRD4ALDH1A1ADORA2B | |
| SCHEMBL2993196 | 0.86 | CNOT7 (0.53) | CNOT7PARNBRD4ALDH1A1ADORA2B | |
| SCHEMBL4420441 | 0.85 | CNOT7 (0.72) | CNOT7PARNBRD4POLBHIF1A | |
| SCHEMBL10812168 | 0.84 | PDE4A (0.53) | CNOT7PARNBRD4ALDH1A1ADORA2B | |
| SCHEMBL9391031 | 0.81 | CNOT7 (0.59) | CNOT7PARNBRD4POLBHIF1A | |
| SCHEMBL9844553 | 0.81 | PDE4A (0.56) | CNOT7PARNBRD4ALDH1A1ADORA2B | |
| SCHEMBL16058255 | 0.81 | CNOT7 (0.58) | CNOT7PARNBRD4POLBHIF1A | |
| SCHEMBL16312820 | 0.80 | CNOT7 (0.57) | CNOT7PARNBRD4POLBHIF1A | |
| SCHEMBL7443281 | 0.80 | CNOT7 (0.46) | CNOT7PARNKMT2AADORA2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531544-B2 | Xanthine phosphodiesterase V inhibitors | SCHERING CORPORATION (US) | 2009-05-12 | — | — | US | disclosed |
| US-7531544-B2 | Xanthine phosphodiesterase V inhibitors | SCHERING CORPORATION (US) | 2009-05-12 | — | — | US | disclosed |
| US-7312223-B2 | 8-Amino-7-phenylmethyl-1-ethyl-3,7-dihydro-3-(2-hydroxyethyl)-purine-2,6-dione derivatives; urogenital, respiratory system, kidney, cardiovascular, autoimmune or brain disorders; angina pectoris, hypertension, restenosis; anticarcinogenic, hypoglycemic, antiischemic, and hypotensive agents; diabetes | SCHERING CORPORATION (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312223-B2 | 8-Amino-7-phenylmethyl-1-ethyl-3,7-dihydro-3-(2-hydroxyethyl)-purine-2,6-dione derivatives; urogenital, respiratory system, kidney, cardiovascular, autoimmune or brain disorders; angina pectoris, hypertension, restenosis; anticarcinogenic, hypoglycemic, antiischemic, and hypotensive agents; diabetes | SCHERING CORPORATION (US) | 2007-12-25 | — | — | US | disclosed |
| US-7268141-B2 | Xanthine phosphodiesterase V inhibitors | SCHERING CORPORATION (US) | 2007-09-11 | — | — | US | disclosed |
| US-7268141-B2 | Xanthine phosphodiesterase V inhibitors | SCHERING CORPORATION (US) | 2007-09-11 | — | — | US | disclosed |