Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 10/20 | 0.57 |
| ▸ | NPC1 | O15118 | 8/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.53 |
| ▸ | RELA | Q04206 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29714984 | 1.00 | TSHR (0.58) | TSHRLMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4420607 | 1.00 | TSHR (0.58) | TSHRLMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6379969 | 0.91 | TSHR (0.70) | TSHRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL6379973 | 0.91 | TSHR (0.70) | TSHRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL11197062 | 0.85 | LMNA (0.55) | TSHRLMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4986237 | 0.85 | MAPT (0.58) | LMNARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL11197060 | 0.85 | LMNA (0.55) | TSHRLMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4986231 | 0.85 | MAPT (0.58) | LMNARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL4414791 | 0.80 | LMNA (0.56) | TSHRLMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4414790 | 0.80 | LMNA (0.56) | TSHRLMNARAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030045725-A1 | Method for the production of aromatic or heteroaromatic aldehydes or ketones by oxidative decarboxylation | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) | 2003-03-06 | — | — | US | claimed |
| EP-1274670-A1 | METHOD FOR THE PRODUCTION OF AROMATIC OR HETEROAROMATIC ALDEHYDES OR KETONES BY OXIDATIVE DECARBOXYLATION | DSM Fine Chemicals Austria Nfg GmbH & Co KG (AT) | 2003-01-15 | — | — | EP | claimed |
| WO-2001079147-A1 | METHOD FOR THE PRODUCTION OF AROMATIC OR HETEROAROMATIC ALDEHYDES OR KETONES BY OXIDATIVE DECARBOXYLATION | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) | 2001-10-25 | — | — | WO | claimed |
| EP-0370454-B1 | Renin-inhibiting amino diol derivatives | HOECHST AG (DE) | 1994-04-20 | — | — | EP | claimed |
| EP-0373549-B1 | AMINO ACID DERIVATIVES WITH ENZYME-INHIBITING PROPERTIES, PROCESS TO SYNTHETISE THEM, COMPOSITION CONTAINING THEM AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-01 | — | — | EP | claimed |
| US-5204357-A | RENIN-INHIBITING AMINO ACID DERIVATIVES | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-04-20 | — | — | US | claimed |
| EP-0373549-A2 | Amino acid derivatives with enzyme-inhibiting properties, process to synthetise them, composition containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-06-20 | — | — | EP | claimed |
| EP-0372537-A2 | Urea derivatives of dipeptides with enzyme-inhibiting properties, process to make them, compositions containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-06-13 | — | — | EP | claimed |
| EP-0370383-A2 | Renin-inhibiting dipeptides, process to make them, compositions containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | claimed |
| EP-0370382-A2 | Urea dipeptide derivatives with a renin-inhibiting activity, process to produce them, compositions containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | claimed |
| EP-0370454-A2 | Renin-inhibiting amino diol derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | claimed |
| EP-0329013-A2 | Renin-inhibiting amino acid derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-08-23 | — | — | EP | claimed |
| EP-0310015-A2 | Renin-inhibiting dipeptides, process for their preparation, medicines containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-04-05 | — | — | EP | claimed |
| EP-0951466-B1 | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | ELAN PHARM INC (US) | 2009-01-21 | — | — | EP | disclosed |
| US-20050272666-A1 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds | WU JING | 2005-12-08 | — | — | US | disclosed |
| US-20040058900-A1 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds | WU JING (US) | 2004-03-25 | — | — | US | disclosed |
| EP-0370382-A2 | Urea dipeptide derivatives with a renin-inhibiting activity, process to produce them, compositions containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | disclosed |
| EP-0370454-A2 | Renin-inhibiting amino diol derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | disclosed |
| EP-0329013-A2 | Renin-inhibiting amino acid derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-08-23 | — | — | EP | disclosed |
| EP-0310015-A2 | Renin-inhibiting dipeptides, process for their preparation, medicines containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-04-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272666-A1 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds | BACE1, APP, BACE2 | TSHR 4512/4885LMNA 1272/4885RAB9A 2465/4885 |
| US-20030045725-A1 | Method for the production of aromatic or heteroaromatic aldehydes or ketones by oxidative decarboxylation | AOX1, ALDH5A1, AOC2 | TSHR 3851/4885LMNA 2627/4885RAB9A 4012/4885 |
| US-20040058900-A1 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds | BACE1, APP, BACE2 | TSHR 4538/4885LMNA 1339/4885RAB9A 2521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.