Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.53 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GBA1 | P04062 | 3/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13573571 | 0.83 | GBA1 (0.59) | S1PR1S1PR5GBA1HRH4HRH3 | |
| SCHEMBL5793338 | 0.82 | FUCA1 (0.58) | S1PR1S1PR5GBA1DRD2DRD3 | |
| SCHEMBL15477204 | 0.82 | FUCA1 (0.58) | S1PR1S1PR5GBA1DRD2DRD3 | |
| SCHEMBL1010709 | 0.82 | FUCA1 (0.58) | S1PR1S1PR5GBA1DRD2DRD3 | |
| SCHEMBL3335710 | 0.82 | FUCA1 (0.58) | S1PR1S1PR5GBA1DRD2DRD3 | |
| SCHEMBL20804087 | 0.82 | ALDH1A1 (0.47) | S1PR1GBA1HRH4HRH3SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL14780326 | 0.81 | FUCA1 (0.56) | S1PR1S1PR5GBA1DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL14780325 | 0.81 | FUCA1 (0.56) | S1PR1S1PR5GBA1DRD2DRD3 | |
| SCHEMBL16081738 | 0.79 | S1PR1 (0.51) | S1PR1S1PR5POLBHRH4HRH3 | |
| SCHEMBL4426362 | 0.79 | S1PR1 (0.51) | S1PR1S1PR5POLBHRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680124-B1 | BICYCLIC [3.1.0] DERIVATIVES AS GLYCINE TRANSPORTER INHIBITORS | PFIZER PROD INC (US) | 2017-05-31 | — | — | EP | disclosed |
| US-7473787-B2 | Bicyclic [3.1.0] derivatives as glycine transporter inhibitors | PFIZER INC (US) | 2009-01-06 | — | — | US | disclosed |
| US-20050096375-A1 | Bicyclic [3.1.0] derivatives as glycine transporter inhibitors | PFIZER INC. | 2005-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096375-A1 | Bicyclic [3.1.0] derivatives as glycine transporter inhibitors | SLC6A5, SLC1A5, SLC6A3 | S1PR1 1598/4885S1PR5 1488/4885POLB 2927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.