Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | CDK9 | P50750 | 3/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | KCNH3 | Q9ULD8 | 3/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | MELK | Q14680 | 1/20 | 0.32 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4413438 | 0.91 | MAPK10 (0.34) | CDK2CDK9CCNT1CCNE1PTGS2 | |
| SCHEMBL4413555 | 0.91 | BRAF (0.38) | CDK2CDK9CCNT1CCNE1PTGS2 | |
| SCHEMBL4414542 | 0.89 | KCNH3 (0.39) | CDK2CDK9CCNT1CCNE1TBK1 | |
| SCHEMBL4412920 | 0.86 | MAPK10 (0.36) | CDK2CDK9CCNT1CCNE1PTGS2 | |
| SCHEMBL4415084 | 0.86 | MAPK10 (0.36) | CDK2CDK9CCNT1CCNE1TBK1 | |
| SCHEMBL4411774 | 0.85 | MAPK10 (0.36) | CDK2CDK9CCNT1CCNE1PTGS2 | |
| SCHEMBL4416830 | 0.85 | BRAF (0.44) | CDK2CDK9CCNT1CCNE1TBK1 | |
| SCHEMBL4410855 | 0.85 | CCNT1 (0.42) | CDK2CDK9CCNT1CCNE1TBK1 | |
| SCHEMBL4410707 | 0.84 | TBK1 (0.38) | CDK2CDK9CCNT1CCNE1TBK1 | |
| SCHEMBL4418433 | 0.84 | CDK2 (0.47) | CDK2CDK9CCNT1CCNE1MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615921-B1 | PYRIDO 2,3-D PYRIMIDIN-7-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | EP | claimed |