Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexane SCHEMBL10358872 | 0.83 | CA1 (0.33) | ALDH1A1 | |
| Bicarbonate SCHEMBL3784747 | 0.83 | CA1 (0.33) | ALDH1A1 | |
| Cyclooctane SCHEMBL9815451 | 0.83 | CA1 (0.33) | ALDH1A1 | |
| Cyclopentane SCHEMBL525206 | 0.83 | CA1 (0.33) | ALDH1A1 | |
| Tetrahydrofuran SCHEMBL1950354 | 0.83 | — | — | |
| Tetrahydrofuran SCHEMBL16166505 | 0.83 | ALDH1A1 (0.61) | ALDH1A1GLAMEN1TP53KMT2A | |
| Tetrahydrofuran SCHEMBL905739 | 0.83 | ALDH1A1 (0.61) | ALDH1A1GLAMEN1TP53KMT2A | |
| Tetrahydrofuran SCHEMBL3294902 | 0.83 | ALDH1A1 (0.61) | ALDH1A1GLAMEN1TP53KMT2A | |
| Tetrahydrofuran SCHEMBL11210398 | 0.80 | ALDH1A1 (0.57) | ALDH1A1GLAMEN1TP53KMT2A | |
| Bicarbonate SCHEMBL8169227 | 0.80 | ALDH1A1 (0.57) | ALDH1A1GLAMEN1TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799791-B1 | PHOTOCROSSLINKABLE MATERIALS | ROLIC AG (CH) | 2016-01-13 | — | — | EP | claimed |
| EP-1771141-B1 | DENTAL ADHESIVE COMPOSITION | DENTSPLY DETREY GMBH (DE) | 2009-03-25 | — | — | EP | claimed |
| EP-0141781-B1 | LIGHT-SENSITIVE COATING COMPOSITION AND USE THEREOF | CIBA-GEIGY AG (CH) | 1991-09-04 | — | — | EP | disclosed |
| EP-0134752-B1 | LAYERED MATERIAL AND ITS USE | CIBA-GEIGY AG (CH) | 1988-01-27 | — | — | EP | disclosed |
| EP-0141781-A2 | Light-sensitive coating composition and use thereof | CIBA-GEIGY AG (CH) | 1985-05-15 | — | — | EP | disclosed |
| EP-0134752-A1 | Layered material and its use | CIBA-GEIGY AG (CH) | 1985-03-20 | — | — | EP | disclosed |
| EP-0005868-B1 | WATER-SOLUBLE REACTIVE BINDING AGENTS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE MANUFACTURE OF COATINGS AND ADHESIVES | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-07-18 | — | — | EP | disclosed |
| EP-0002284-B1 | REACTIVE CURABLE POLYMER MIXTURE AND PROCESS FOR PREPARING CURED PRODUCTS THEREFROM | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-02-01 | — | — | EP | disclosed |
| EP-0005868-A1 | Water-soluble reactive binding agents, process for their preparation and their use in the manufacture of coatings and adhesives | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-12-12 | — | — | EP | disclosed |
| EP-0002284-A1 | Reactive curable polymer mixture and process for preparing cured products therefrom | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-06-13 | — | — | EP | disclosed |