Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.72 |
| ▸ | SLC6A5 | Q9Y345 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 6/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423549 | 0.87 | ALDH1A1 (0.83) | ALDH1A1SLC6A9SLC6A5LMNASMN1; SMN2 | |
| SCHEMBL18983851 | 0.84 | SLC6A9 (0.66) | ALDH1A1SLC6A9SLC6A5LMNASMN1; SMN2 | |
| SCHEMBL3932988 | 0.84 | SLC6A9 (1.00) | SLC6A9SLC6A5SMN1; SMN2 | |
| SCHEMBL4423014 | 0.81 | LMNA (1.00) | ALDH1A1SLC6A9SLC6A5LMNASMN1; SMN2 | |
| SCHEMBL4421403 | 0.80 | LMNA (0.91) | ALDH1A1SLC6A9SLC6A5LMNASMN1; SMN2 | |
| SCHEMBL27771404 | 0.79 | LMNA (0.68) | ALDH1A1SLC6A9SLC6A5LMNASMN1; SMN2 | |
| SCHEMBL4423531 | 0.77 | ALDH1A1 (0.72) | ALDH1A1SLC6A9SLC6A5LMNASMN1; SMN2 | |
| SCHEMBL4420325 | 0.77 | SLC6A9 (0.73) | ALDH1A1SLC6A9SLC6A5LMNASMN1; SMN2 | |
| SCHEMBL14410957 | 0.76 | ENPP2 (0.68) | ALDH1A1SLC6A9SLC6A5LMNASMN1; SMN2 | |
| SCHEMBL4424444 | 0.76 | KMT2A (0.78) | ALDH1A1SLC6A9SLC6A5LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1703909-B1 | 1-BENZOYL-PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES | HOFFMANN LA ROCHE (CH) | 2009-04-15 | — | — | EP | claimed |