Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 17/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099068 | 0.81 | TNF (0.39) | TNFLMNAEP300 | |
| SCHEMBL4414209 | 0.73 | PLA2G7 (0.46) | — | |
| SCHEMBL7006492 | 0.71 | TNF (0.40) | TNFLMNA | |
| SCHEMBL5867433 | 0.71 | TNF (0.43) | TNFLMNA | |
| SCHEMBL4425565 | 0.71 | TNF (0.40) | TNFLMNA | |
| SCHEMBL7012983 | 0.68 | EP300 (0.40) | TNFLMNAEP300 | |
| SCHEMBL4411686 | 0.66 | L3MBTL1 (0.41) | TNFLMNA | |
| SCHEMBL7099070 | 0.65 | TNF (0.41) | TNFLMNAEP300 | |
| SCHEMBL12657435 | 0.64 | LMNA (0.85) | TNFLMNA | |
| SCHEMBL27745079 | 0.62 | PDE4A (0.52) | TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |