SCHEMBL4425629

SCHEMBL4425629

COC(c1ccc(C(=O)C(C)(C)OC)cc1)c1ccc(C(=O)C(C)(C)OC)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 2/20 0.36
RARA P10276 1/20 0.35
RARB P10826 1/20 0.35
RARG P13631 1/20 0.35
MLKL Q8NB16 3/20 0.35
CHEK2 O96017 1/20 0.34
MLYCD O95822 1/20 0.34
NPSR1 Q6W5P4 1/20 0.33
SRC P12931 1/20 0.33
ELANE P08246 1/20 0.32
GABBR2 O75899 1/20 0.31
GABBR1 Q9UBS5 1/20 0.31
ESR1 P03372 1/20 0.31
ESR2 Q92731 1/20 0.31
CES2 O00748 1/20 0.31
NR1H4 Q96RI1 1/20 0.30
MAPT P10636 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3088741 0.84 SRC (0.37) CES1RARARARBRARGMLKL
SCHEMBL9246353 0.84 CYP2C9 (0.44) MLYCDMAPTMEN1KMT2ARAB9A
SCHEMBL3682124 0.84 ESR1 (0.39) CES1MLYCDNPSR1SRCELANE
Methoxymethane SCHEMBL4418025 0.82 SRC (0.36) CES1RARARARBRARGMLKL
SCHEMBL4427192 0.82 RARA (0.35) CES1RARARARBRARGMLKL
SCHEMBL4425679 0.79 ALDH1A1 (0.34) CES1RARARARBRARGMLKL
SCHEMBL3678671 0.78 SRC (0.44) CES1RARARARBRARGMLKL
SCHEMBL3689405 0.78 KMT2A (0.50) CES1ELANENR1H4MEN1KMT2A
SCHEMBL10712634 0.77 TDP1 (0.52) CES1NPSR1CES2MAPTMEN1
SCHEMBL18678827 0.76 TPMT (0.45) CES1MLYCDSRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1620475-B1 NOVEL TRIFUNCTIONAL PHOTOINITIATORS BASF SE (DE) 2009-11-11 EP disclosed
US-7462650-B2 Trifunctional photoinitiators CIBA SPECIALTY CHEMICALS CORPORATION (US) 2008-12-09 US disclosed
US-20060270748-A1 Novel trifunctional photoinitiators IGM GROUP B.V. (NL) 2006-11-30 US disclosed
EP-1620475-A1 NOVEL TRIFUNCTIONAL PHOTOINITIATORS Ciba SC Holding AG (CH) 2006-02-01 EP disclosed
WO-2004099262-A1 NOVEL TRIFUNCTIONAL PHOTOINITIATORS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2004-11-18 WO disclosed