Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29289233 | 0.85 | PKM (0.67) | PKML3MBTL1KDM4EALDH1A1MEN1 | |
| SCHEMBL29289228 | 0.85 | PKM (0.67) | PKML3MBTL1KDM4EALDH1A1MEN1 | |
| SCHEMBL4419297 | 0.78 | KDM4E (0.72) | PKML3MBTL1MAOBAPPKDM4E | |
| SCHEMBL11450459 | 0.76 | APP (0.61) | MAOBBCHEAPPKDM4EALDH1A1 | |
| SCHEMBL11450460 | 0.76 | APP (0.61) | MAOBBCHEAPPKDM4EALDH1A1 | |
| SCHEMBL29289251 | 0.74 | ALDH1A1 (0.60) | PKML3MBTL1MAOBKDM4EALDH1A1 | |
| SCHEMBL29289250 | 0.74 | ALDH1A1 (0.60) | PKML3MBTL1MAOBKDM4EALDH1A1 | |
| SCHEMBL9364776 | 0.74 | MAPT (0.56) | MAOBBCHEAPPKDM4EALDH1A1 | |
| SCHEMBL9364774 | 0.74 | MAPT (0.56) | MAOBBCHEAPPKDM4EALDH1A1 | |
| SCHEMBL11757992 | 0.73 | PKM (0.78) | PKML3MBTL1KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197660-A1 | Compounds for modulating cell proliferation | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-08-23 | — | — | US | claimed |
| EP-1654220-A4 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HOSPITAL FOR SICK CHILDREN (CA) | 2006-10-25 | — | — | EP | claimed |
| EP-1654220-A1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | The Hospital for Sick Children (CA) | 2006-05-10 | — | — | EP | claimed |
| US-20050085538-A1 | Compounds for modulating cell proliferation | HOSPITAL FOR SICK CHILDREN, THE (CA) | 2005-04-21 | — | — | US | claimed |
| WO-2005012234-A1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2005-02-10 | — | — | WO | claimed |
| EP-1467967-A1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | The Hospital for Sick Children (CA) | 2004-10-20 | — | — | EP | claimed |
| WO-2003062190-A1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2003-07-31 | — | — | WO | claimed |
| US-7563820-B2 | Compounds for modulating cell proliferation | THE HOSPITAL FOR SICK CHILDREN (CA) | 2009-07-21 | — | — | US | disclosed |
| US-7563820-B2 | Compounds for modulating cell proliferation | THE HOSPITAL FOR SICK CHILDREN (CA) | 2009-07-21 | — | — | US | disclosed |
| US-20070197660-A1 | Compounds for modulating cell proliferation | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-08-23 | — | — | US | disclosed |
| US-20070197660-A1 | Compounds for modulating cell proliferation | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-08-23 | — | — | US | disclosed |
| US-20070197660-A1 | Compounds for modulating cell proliferation | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-08-23 | — | — | US | disclosed |
| US-20060241084-A1 | Inhibition of vascular endothelial growth factor | THE HOSPITAL FOR SICK CHILDREN (CA) | 2006-10-26 | — | — | US | disclosed |
| EP-1551381-A2 | STYRYLACRYLONITRILE COMPOUNDS FOR INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR | The Hospital for Sick Children (CA) | 2005-07-13 | — | — | EP | disclosed |
| US-20050085538-A1 | Compounds for modulating cell proliferation | HOSPITAL FOR SICK CHILDREN, THE (CA) | 2005-04-21 | — | — | US | disclosed |
| EP-1467967-A1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | The Hospital for Sick Children (CA) | 2004-10-20 | — | — | EP | disclosed |
| WO-2004032911-A2 | STYRYLACRYLONITRILE COMPOUNDS FOR INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR | THE HOSPITAL FOR SICK CHILDREN (CA) | 2004-04-22 | — | — | WO | disclosed |
| WO-2003062190-A1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | THE HOSPITAL FOR SICK CHILDREN (CA) | 2003-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241084-A1 | Inhibition of vascular endothelial growth factor | VEGFA, FLT4, FLT1 | PKM 2600/4885L3MBTL1 4534/4885MAOB 495/4885 |
| US-20050085538-A1 | Compounds for modulating cell proliferation | CCNO, CCNY, CCND3 | PKM 4377/4885L3MBTL1 1668/4885MAOB 1268/4885 |
| US-20070197660-A1 | Compounds for modulating cell proliferation | CCND3, CCNO, WNT3 | PKM 4355/4885L3MBTL1 771/4885MAOB 2008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.