Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 9/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | ITGAV | P06756 | 4/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.44 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.44 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5151908 | 0.90 | ITGB3 (0.57) | ITGB3ITGA2BGAAKMT2ANPC1 | |
| SCHEMBL688684 | 0.83 | ITGB3 (0.53) | ITGB3ITGA2BGAAKMT2ANPC1 | |
| SCHEMBL3141349 | 0.77 | ITGB3 (0.58) | ITGB3ITGA2BGAAKMT2ARAB9A | |
| SCHEMBL4854580 | 0.77 | GSK3B (0.51) | ITGB3ITGA2BKMT2ANPC1HPGD | |
| SCHEMBL4855345 | 0.77 | GSK3B (0.51) | ITGB3ITGA2BKMT2ANPC1HPGD | |
| SCHEMBL4426774 | 0.76 | KMT2A (0.50) | ITGB3ITGA2BKMT2AITGAV | |
| SCHEMBL4427887 | 0.76 | ITGB3 (0.47) | ITGB3ITGA2BITGAVITGB5ITGB6 | |
| SCHEMBL4855596 | 0.76 | RAB9A (0.52) | ITGB3ITGA2BGAAKMT2ANPC1 | |
| SCHEMBL13118325 | 0.74 | FFAR1 (0.57) | KMT2AFFAR1 | |
| SCHEMBL6352863 | 0.73 | ITGB3 (0.74) | ITGB3ITGA2BKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1213288-B1 | Propanoic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2009-01-14 | — | — | EP | disclosed |
| EP-1213288-A1 | Propanoic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-06-12 | — | — | EP | disclosed |