Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 10/20 | 0.57 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ITGAV | P06756 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.49 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.49 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4426523 | 0.90 | ITGB3 (0.51) | ITGB3ITGA2BNPC1RAB9AHPGD | |
| SCHEMBL3141349 | 0.83 | ITGB3 (0.58) | ITGB3ITGA2BRAB9AKMT2AMEN1 | |
| SCHEMBL4854580 | 0.83 | GSK3B (0.51) | ITGB3ITGA2BNPC1RAB9AHPGD | |
| SCHEMBL4855345 | 0.83 | GSK3B (0.51) | ITGB3ITGA2BNPC1RAB9AHPGD | |
| SCHEMBL4855596 | 0.81 | RAB9A (0.52) | ITGB3ITGA2BNPC1RAB9AHPGD | |
| SCHEMBL19614361 | 0.80 | RAB9A (0.55) | NPC1RAB9AHPGDKMT2AKDM4E | |
| SCHEMBL19614362 | 0.80 | RAB9A (0.55) | NPC1RAB9AHPGDKMT2AKDM4E | |
| SCHEMBL6438227 | 0.80 | ALDH1A1 (0.46) | ITGB3ITGA2BNPC1RAB9AHPGD | |
| SCHEMBL4427887 | 0.80 | ITGB3 (0.47) | ITGB3ITGA2BKDM4EITGAVPOLB | |
| SCHEMBL4426774 | 0.80 | KMT2A (0.50) | ITGB3ITGA2BKMT2AMEN1ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7157454-B2 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2007-01-02 | — | — | US | disclosed |
| US-20040116353-A1 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same | SANOFI (FR) | 2004-06-17 | — | — | US | disclosed |