Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 6/20 | 0.53 |
| ▸ | ITGAV | P06756 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | CCR2 | P41597 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4426523 | 0.83 | ITGB3 (0.51) | ITGB3ITGAVKMT2ARAB9ANPC1 | |
| SCHEMBL3141349 | 0.81 | ITGB3 (0.58) | ITGB3ITGAVKMT2ARAB9AMEN1 | |
| SCHEMBL688065 | 0.79 | RAB9A (0.55) | ITGB3ITGAVKMT2ARAB9ANPC1 | |
| SCHEMBL27553620 | 0.79 | RAB9A (0.55) | ITGB3ITGAVKMT2ARAB9ANPC1 | |
| SCHEMBL6352863 | 0.79 | ITGB3 (0.74) | ITGB3ITGAVKMT2ARAB9ANPC1 | |
| SCHEMBL27182521 | 0.78 | ITGB3 (0.56) | ITGB3ITGAVKMT2ARAB9ANPC1 | |
| SCHEMBL7834692 | 0.78 | ITGB3 (0.54) | ITGB3ITGAVKMT2ARAB9ANPC1 | |
| SCHEMBL686712 | 0.77 | ITGB3 (0.52) | ITGB3ITGAVKMT2ARAB9ANPC1 | |
| SCHEMBL688104 | 0.77 | ITGB3 (0.47) | ITGB3ITGAVKMT2ARAB9ANPC1 | |
| SCHEMBL5151908 | 0.76 | ITGB3 (0.57) | ITGB3ITGAVKMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1176956-B1 | CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | ENCYSIVE PHARMACEUTICALS INC (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |