Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9560340 | 0.76 | BRD4 (0.52) | BRD4HCRTR1HCRTR2CYP11B2FFAR2 | |
| SCHEMBL26772897 | 0.66 | CHRNB4 (0.59) | BRD4CYP11B2 | |
| SCHEMBL31229667 | 0.65 | CHRNB2 (0.53) | BRD4HCRTR1HCRTR2CYP11B2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7688522 | 0.65 | CHRNB4 (0.57) | BRD4CYP11B2 | |
| Phosphoric Acid SCHEMBL29542627 | 0.65 | ALDH1A1 (0.52) | HDAC4HDAC2HDAC8HDAC6ALDH1A1 | |
| Phosphoric Acid SCHEMBL1281473 | 0.65 | ALDH1A1 (0.52) | HDAC4HDAC2HDAC8HDAC6ALDH1A1 | |
| Phosphoric Acid SCHEMBL242260 | 0.63 | ALDH1A1 (0.50) | HDAC4HDAC2HDAC8HDAC6ALDH1A1 | |
| SCHEMBL621942 | 0.63 | BRD4 (0.47) | BRD4HCRTR1HCRTR2ADRA2AADRA1D | |
| SCHEMBL13454056 | 0.63 | TP53 (0.58) | BRD4HCRTR1HCRTR2CYP11B2ADRA2A | |
| SCHEMBL23323089 | 0.63 | CYP11B2 (0.49) | BRD4HCRTR1HCRTR2CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099355-A1 | Processes for Production of 4-(Biphenylyl)Azetidin-2-One Phosphonic Acids | MICROBIA, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| US-20090099355-A1 | Processes for Production of 4-(Biphenylyl)Azetidin-2-One Phosphonic Acids | MICROBIA, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| US-20090099355-A1 | Processes for Production of 4-(Biphenylyl)Azetidin-2-One Phosphonic Acids | MICROBIA, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| CN-101222950-A | Processes for production of 4-(biphenylyl)azetidin-2-one phosphonic acids | MICROBIA INC (US) | 2008-07-16 | — | — | CN | disclosed |
| CN-101222950-A | Processes for production of 4-(biphenylyl)azetidin-2-one phosphonic acids | MICROBIA INC (US) | 2008-07-16 | — | — | CN | disclosed |
| EP-1896135-A2 | PROCESSES FOR PRODUCTION OF 4-(BIPHENYLYL)AZETIDIN-2-ONE PHOSPHONIC ACIDS | Microbia, Inc. (US) | 2008-03-12 | — | — | EP | disclosed |
| EP-1896135-A2 | PROCESSES FOR PRODUCTION OF 4-(BIPHENYLYL)AZETIDIN-2-ONE PHOSPHONIC ACIDS | Microbia, Inc. (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006127893-A3 | PROCESSES FOR PRODUCTION OF 4-(BIPHENYLYL)AZETIDIN-2-ONE PHOSPHONIC ACIDS | MICROBIA INC (US) | 2007-03-08 | — | — | WO | disclosed |
| WO-2006127893-A2 | PROCESSES FOR PRODUCTION OF 4-(BIPHENYLYL)AZETIDIN-2-ONE PHOSPHONIC ACIDS | MICROBIA, INC. (US) | 2006-11-30 | — | — | WO | disclosed |
| WO-2006127893-A2 | PROCESSES FOR PRODUCTION OF 4-(BIPHENYLYL)AZETIDIN-2-ONE PHOSPHONIC ACIDS | MICROBIA, INC. (US) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099355-A1 | Processes for Production of 4-(Biphenylyl)Azetidin-2-One Phosphonic Acids | PIK3CA, PPA1, PIK3CB | BRD4 3758/4885HCRTR1 4853/4885HCRTR2 4729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.