Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 10/20 | 0.43 |
| ▸ | CMA1 | P23946 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | CPA1 | P15085 | 1/20 | 0.34 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.34 |
| ▸ | FPR1 | P21462 | 2/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4426739 | 0.93 | CASP1 (0.42) | CASP1CMA1MAPTFPR1FPR2 | |
| SCHEMBL4435242 | 0.92 | CASP1 (0.37) | CASP1CMA1GPR88CYP3A4CYP2C9 | |
| SCHEMBL4436767 | 0.91 | CASP1 (0.39) | CASP1GPR88KMT2AFPR1 | |
| SCHEMBL4426779 | 0.91 | FPR1 (0.37) | CASP1GPR88KMT2ASMN1; SMN2FPR1 | |
| SCHEMBL4434290 | 0.90 | FPR1 (0.39) | CASP1GPR88CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4424304 | 0.90 | FPR1 (0.44) | CASP1SMN1; SMN2FPR1FPR2 | |
| SCHEMBL4427169 | 0.89 | FPR1 (0.37) | CASP1GPR88KMT2ASMN1; SMN2FPR1 | |
| SCHEMBL4434041 | 0.88 | FPR1 (0.35) | CASP1GPR88KMT2ASMN1; SMN2FPR1 | |
| SCHEMBL4436791 | 0.87 | KMT2A (0.36) | CASP1GPR88KMT2ASMN1; SMN2FPR1 | |
| SCHEMBL6759875 | 0.85 | FPR1 (0.43) | CASP1MAPTGPR88MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1213288-B1 | Propanoic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2009-01-14 | — | — | EP | disclosed |
| EP-1213288-A1 | Propanoic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-06-12 | — | — | EP | disclosed |