Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4436626 | 0.84 | CFTR (0.46) | KDM4EGLAGAAALDH1A1MEN1 | |
| SCHEMBL4437347 | 0.84 | GAA (0.51) | KDM4EGLAGAAALDH1A1PARP1 | |
| SCHEMBL4439660 | 0.84 | KDM4E (0.41) | KDM4EGAAHDAC4HDAC7HDAC5 | |
| SCHEMBL4431487 | 0.84 | KDM4E (0.54) | KDM4EGLAGAAALDH1A1KMT2A | |
| SCHEMBL4429591 | 0.79 | GAA (0.51) | KDM4EGLAGAAALDH1A1KMT2A | |
| SCHEMBL4426018 | 0.77 | KDM4E (0.49) | KDM4EGLAGAAALDH1A1MEN1 | |
| SCHEMBL4438805 | 0.76 | HSD17B2 (0.48) | KDM4EGLAGAARAB9AHSD17B2 | |
| SCHEMBL4898553 | 0.75 | KDM4E (0.60) | KDM4EGLAGAAALDH1A1MAPT | |
| SCHEMBL4428809 | 0.72 | DAO (0.48) | KDM4EGLAGAAALDH1A1MAPT | |
| SCHEMBL4430946 | 0.71 | HSD17B2 (0.46) | KDM4EGAAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |