Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | GUSB | P08236 | 1/20 | 0.43 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438805 | 0.85 | HSD17B2 (0.48) | CFTRKDM4EGLAGAAHSD17B2 | |
| SCHEMBL4427283 | 0.84 | KDM4E (0.47) | KDM4EGLAGAACES2HSD17B2 | |
| SCHEMBL4431487 | 0.81 | KDM4E (0.54) | CFTRKDM4EGLAGAANPSR1 | |
| SCHEMBL12427050 | 0.77 | CFTR (0.52) | CFTRKDM4EGLAGAAGUSB | |
| SCHEMBL4429591 | 0.76 | GAA (0.51) | KDM4EGLAGAAHSD17B2MAPT | |
| SCHEMBL4437347 | 0.76 | GAA (0.51) | KDM4EGLAGAAHSD17B2MAPT | |
| SCHEMBL4898553 | 0.72 | KDM4E (0.60) | CFTRKDM4EGLAGAANPSR1 | |
| SCHEMBL4429494 | 0.70 | KCNN4 (0.44) | CFTRKDM4EKCNN4CES2NPSR1 | |
| SCHEMBL3056728 | 0.70 | KDM4E (0.60) | KDM4EGLAGAAHSD17B2 | |
| SCHEMBL6567957 | 0.69 | CFTR (0.48) | CFTRKDM4EGAAKCNN4CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |