Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4431487 | 0.86 | KDM4E (0.54) | GAAKDM4EGLASLC6A3RAB9A | |
| SCHEMBL4438805 | 0.85 | HSD17B2 (0.48) | GAAKDM4EGLARAB9AHSD17B2 | |
| SCHEMBL4427283 | 0.84 | KDM4E (0.47) | GAAKDM4EGLARAB9ANPC1 | |
| SCHEMBL4429591 | 0.81 | GAA (0.51) | GAAKDM4EGLARAB9ACYP1A2 | |
| SCHEMBL4898553 | 0.79 | KDM4E (0.60) | GAAKDM4EGLASMN1; SMN2TSHR | |
| SCHEMBL4426018 | 0.78 | KDM4E (0.49) | GAAKDM4EGLASLC6A4SLC6A3 | |
| SCHEMBL4436626 | 0.76 | CFTR (0.46) | GAAKDM4EGLASMN1; SMN2MEN1 | |
| SCHEMBL1547993 | 0.75 | KDM4E (0.55) | GAAKDM4EGLASLC6A4SLC6A3 | |
| SCHEMBL3913842 | 0.72 | KDM4E (0.51) | GAAKDM4EGLASLC6A4SLC6A3 | |
| SCHEMBL10464803 | 0.69 | KDM4E (1.00) | GAAKDM4EGLASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |