Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437347 | 0.86 | GAA (0.51) | KDM4EGAAGLAALDH1A1MAPT | |
| SCHEMBL4427283 | 0.84 | KDM4E (0.47) | KDM4EGAAGLAALDH1A1MAPT | |
| SCHEMBL4429591 | 0.83 | GAA (0.51) | KDM4EGAAGLAALDH1A1MAPT | |
| SCHEMBL4427252 | 0.83 | KDM4E (0.53) | KDM4EGAAALDH1A1MAPTHSD17B2 | |
| SCHEMBL4438805 | 0.82 | HSD17B2 (0.48) | KDM4EGAAGLAHSD17B2CFTR | |
| SCHEMBL4436626 | 0.81 | CFTR (0.46) | KDM4EGAAGLAALDH1A1MAPT | |
| SCHEMBL4898553 | 0.78 | KDM4E (0.60) | KDM4EGAAGLAALDH1A1MAPT | |
| SCHEMBL4432510 | 0.75 | KDM4E (0.49) | KDM4EGAAGLAALDH1A1MAPT | |
| SCHEMBL4437640 | 0.74 | KDM4E (0.68) | KDM4EGAAGLAALDH1A1MAPT | |
| SCHEMBL4429436 | 0.72 | KDM4E (0.53) | KDM4EGAAGLAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |