Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429520 | 0.84 | KDM4E (0.42) | GAAKDM4EALDH1A1HSD17B2HPGD | |
| SCHEMBL4431487 | 0.83 | KDM4E (0.54) | GAAKDM4EGLAMAPTALDH1A1 | |
| SCHEMBL4437347 | 0.81 | GAA (0.51) | GAAKDM4EGLAMAPTALDH1A1 | |
| SCHEMBL4427283 | 0.79 | KDM4E (0.47) | GAAKDM4EGLAMAPTKDM5A | |
| SCHEMBL4438805 | 0.77 | HSD17B2 (0.48) | GAAKDM4EGLARAB9AHSD17B2 | |
| SCHEMBL4436626 | 0.76 | CFTR (0.46) | GAAKDM4EGLAMAPTALDH1A1 | |
| SCHEMBL4898553 | 0.76 | KDM4E (0.60) | GAAKDM4EGLAMAPTALDH1A1 | |
| SCHEMBL4426018 | 0.73 | KDM4E (0.49) | GAAKDM4EGLAMAPTALDH1A1 | |
| SCHEMBL4430946 | 0.72 | HSD17B2 (0.46) | GAAKDM4EKDM5AALDH1A1HSD17B2 | |
| SCHEMBL4734537 | 0.72 | KDM4E (0.68) | GAAKDM4EGLAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |