Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44935 | 0.86 | POLB (0.49) | POLBALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL46488 | 0.83 | KDM4E (0.57) | POLBALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL44657 | 0.83 | KDM4E (0.52) | POLBALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL43747 | 0.80 | NOTUM (0.53) | POLBALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL44717 | 0.75 | RAB9A (0.58) | POLBALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL44509 | 0.74 | L3MBTL1 (0.60) | POLBALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL44298 | 0.73 | POLB (0.45) | POLBALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL13844940 | 0.73 | MAPT (0.46) | POLBKMT2AMEN1TSHRLMNA | |
| SCHEMBL25263897 | 0.73 | KDM4E (0.65) | POLBALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL44625 | 0.72 | MAPT (0.44) | POLBALDH1A1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |