Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.52 |
| ▸ | RAB9A | P51151 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 6/20 | 0.52 |
| ▸ | PKM | P14618 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL43747 | 0.85 | NOTUM (0.53) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL44280 | 0.83 | POLB (0.51) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL44465 | 0.83 | MAPK1 (0.45) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL44509 | 0.82 | L3MBTL1 (0.60) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL44717 | 0.80 | RAB9A (0.58) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL44368 | 0.79 | SMN1; SMN2 (0.43) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL44466 | 0.76 | BACE1 (0.48) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL25789107 | 0.74 | KDM4E (0.60) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2089122 | 0.74 | RAB9A (0.69) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL25789344 | 0.73 | KDM4E (0.58) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |