Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
| ▸ | ACP1 | P24666 | 1/20 | 0.32 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.32 |
| ▸ | CASR | P41180 | 4/20 | 0.31 |
| ▸ | PHGDH | O43175 | 2/20 | 0.31 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428090 | 0.80 | KCNH2 (0.41) | MEN1KMT2ATMEM97KCNH2CASR | |
| SCHEMBL4428027 | 0.79 | CASR (0.48) | MEN1KMT2ATMEM97CASR | |
| SCHEMBL4440361 | 0.78 | MEN1 (0.53) | MEN1KMT2ATMEM97KCNH2ACP1 | |
| SCHEMBL3730902 | 0.77 | MEN1 (0.43) | MEN1KMT2ATMEM97KCNH2SORT1 | |
| SCHEMBL4429764 | 0.75 | CASR (0.41) | MEN1KMT2ATMEM97CASR | |
| SCHEMBL2320170 | 0.74 | CCR3 (0.42) | MEN1KMT2ATMEM97KCNH2 | |
| SCHEMBL8163235 | 0.73 | KCNH2 (0.51) | MEN1KMT2ATMEM97KCNH2FDFT1 | |
| SCHEMBL14238201 | 0.72 | HCRTR1 (0.37) | MEN1KMT2AKCNH2SORT1CASR | |
| SCHEMBL3732574 | 0.72 | HCRTR1 (0.43) | — | |
| SCHEMBL3732570 | 0.72 | HCRTR1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |