Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 3/20 | 0.35 |
| ▸ | KDM4A | O75164 | 3/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.35 |
| ▸ | HIF1AN | Q9NWT6 | 3/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4426018 | 0.83 | KDM4E (0.49) | KDM4ECES2CES1GAAALDH1A1 | |
| SCHEMBL4431362 | 0.82 | KDM4E (0.46) | KDM4ENAPRTGAAALDH1A1KMT2A | |
| SCHEMBL4427252 | 0.80 | KDM4E (0.53) | KDM4ENAPRTGAAALDH1A1KMT2A | |
| SCHEMBL4439660 | 0.74 | KDM4E (0.41) | KDM4ECES2CES1NAPRTGAA | |
| SCHEMBL3071414 | 0.74 | KDM4E (0.49) | KDM4ENAPRTGAAALDH1A1KMT2A | |
| SCHEMBL5124119 | 0.71 | KDM4E (0.49) | KDM4ENAPRTGAAALDH1A1KDM6B | |
| SCHEMBL4428254 | 0.70 | HSD17B2 (0.49) | KDM4ECES2CES1ALDH1A1KMT2A | |
| SCHEMBL4429520 | 0.69 | KDM4E (0.42) | KDM4ENAPRTGAAALDH1A1LMNA | |
| SCHEMBL4430946 | 0.69 | HSD17B2 (0.46) | KDM4EGAAALDH1A1KMT2ANOTUM | |
| Phthalic Acid SCHEMBL3628215 | 0.65 | CES2 (0.54) | CES2CES1ALBGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |