Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ACP3 | P15309 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428130 | 0.82 | KDM4E (0.46) | KDM4EHSD17B2GAAMAPTALDH1A1 | |
| SCHEMBL4427252 | 0.80 | KDM4E (0.53) | KDM4EHSD17B2GAAMAPTALDH1A1 | |
| SCHEMBL4429520 | 0.75 | KDM4E (0.42) | KDM4EHSD17B2GAAHPGDHSD17B10 | |
| SCHEMBL4430946 | 0.74 | HSD17B2 (0.46) | KDM4EHSD17B2GAAHPGDHSD17B10 | |
| SCHEMBL5124119 | 0.74 | KDM4E (0.49) | KDM4EGAAHPGDHSD17B10ALDH1A1 | |
| SCHEMBL3071414 | 0.71 | KDM4E (0.49) | KDM4EHSD17B2GAAHPGDHSD17B10 | |
| SCHEMBL21798220 | 0.70 | KDM4E (0.53) | KDM4EHSD17B2GAAHPGDHSD17B10 | |
| SCHEMBL4439660 | 0.69 | KDM4E (0.41) | KDM4EGAANAPRTNOTUMKMT2A | |
| SCHEMBL2594966 | 0.68 | SPR (0.56) | KDM4EGAAHPGDHSD17B10ALDH1A1 | |
| SCHEMBL15177713 | 0.68 | LMNA (0.34) | KDM4EHSD17B2HPGDMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |