Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 1/20 | 0.42 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | PNP | P00491 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KDM6B | O15054 | 2/20 | 0.37 |
| ▸ | KDM4A | O75164 | 2/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.37 |
| ▸ | HIF1AN | Q9NWT6 | 2/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432534 | 0.85 | KDM4E (0.49) | CAPN1KDM4EPNPTDP1NPC1 | |
| SCHEMBL4425949 | 0.84 | NOTUM (0.42) | CAPN1RXRARXRBKDM4ETDP1 | |
| SCHEMBL3920671 | 0.84 | DAO (0.54) | KDM4EKDM4AKDM5BLMNAKDM4C | |
| SCHEMBL11836193 | 0.82 | KDM4E (0.42) | KDM4EKDM6BKDM4AKDM4DHIF1AN | |
| SCHEMBL4428237 | 0.82 | KDM4E (0.50) | CAPN1KDM4EKDM6BKDM4AKDM4D | |
| SCHEMBL3912930 | 0.82 | KDM4E (0.53) | CAPN1KDM4EKDM6BKDM4AKDM4D | |
| SCHEMBL4430485 | 0.81 | KDM4E (0.41) | KDM4EKDM6BKDM4AKDM4DHIF1AN | |
| SCHEMBL3917621 | 0.81 | DAO (0.46) | KDM4EKDM6BKDM4AKDM4DHIF1AN | |
| SCHEMBL11835232 | 0.80 | KDM4E (0.59) | KDM4ETDP1NPC1RAB9APOLB | |
| SCHEMBL4438825 | 0.80 | BRS3 (0.42) | KDM4ELMNAALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |