Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 7/20 | 0.40 |
| ▸ | KDM4A | O75164 | 5/20 | 0.40 |
| ▸ | KDM6B | O15054 | 4/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.40 |
| ▸ | HIF1AN | Q9NWT6 | 4/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.40 |
| ▸ | KDM3B | Q7LBC6 | 3/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | MDM4 | O15151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429488 | 0.84 | PDE3B (0.47) | KDM4EALDH1A1CA1CA2MAPT | |
| SCHEMBL4428346 | 0.84 | CAPN1 (0.42) | CAPN1KDM5BKDM4AKDM6BKDM4D | |
| SCHEMBL4432424 | 0.82 | HNF4A (0.49) | KDM5BKDM4AKDM6BKDM4DHIF1AN | |
| SCHEMBL3912930 | 0.80 | KDM4E (0.53) | CAPN1KDM5BKDM4AKDM6BKDM4D | |
| SCHEMBL4430684 | 0.80 | RXRA (0.41) | NOTUMRXRARXRBRXRGKDM4E | |
| SCHEMBL4431491 | 0.80 | HCAR2 (0.54) | KDM5BKDM4AKDM6BKDM4DHIF1AN | |
| SCHEMBL4430692 | 0.80 | KDM4E (0.51) | KDM5BKDM4AKDM6BKDM4DHIF1AN | |
| SCHEMBL4380912 | 0.80 | HCAR2 (0.54) | KDM5BKDM4AKDM4EKDM4CDAO | |
| SCHEMBL4438623 | 0.80 | HCAR2 (0.54) | KDM4EDAOBRS3 | |
| SCHEMBL4438787 | 0.80 | KDM4E (0.41) | KDM5BKDM4AKDM6BKDM4DHIF1AN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |