Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4424973 | 0.99 | MEN1 (0.46) | MEN1KMT2ANPC1RAB9APLA2G2A | |
| SCHEMBL4426908 | 0.99 | MEN1 (0.46) | MEN1KMT2ANPC1RAB9APLA2G2A | |
| SCHEMBL4422551 | 0.97 | PLA2G2A (0.44) | MEN1KMT2ANPC1RAB9APLA2G2A | |
| SCHEMBL4418668 | 0.86 | PLA2G2A (0.43) | MEN1KMT2ANPC1RAB9APLA2G2A | |
| SCHEMBL3917712 | 0.86 | ALDH1A1 (0.57) | MEN1KMT2ANPC1RAB9APLA2G2A | |
| SCHEMBL3931017 | 0.85 | ALDH1A1 (0.58) | MEN1KMT2ANPC1RAB9APLA2G2A | |
| SCHEMBL3918365 | 0.85 | ALDH1A1 (0.58) | MEN1KMT2ANPC1RAB9APLA2G2A | |
| SCHEMBL4427086 | 0.85 | PLA2G2A (0.42) | MEN1KMT2ANPC1RAB9APLA2G2A | |
| SCHEMBL4416088 | 0.85 | PLA2G2A (0.42) | MEN1KMT2ANPC1RAB9APLA2G2A | |
| SCHEMBL4426602 | 0.85 | PLA2G2A (0.42) | NPC1RAB9APLA2G2AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583742-B1 | CB 1 RECEPTOUR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2009-12-02 | — | — | EP | claimed |