Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.49 |
| ▸ | CTSK | P43235 | 3/20 | 0.46 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 3/20 | 0.37 |
| ▸ | PLG | P00747 | 2/20 | 0.37 |
| ▸ | PLAT | P00750 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.37 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428775 | 0.87 | ACE (0.53) | ACECTSKANPEPCHRNB2CHRNB4 | |
| SCHEMBL6064942 | 0.83 | ANPEP (0.42) | ACEANPEPF2PLGPLAT | |
| SCHEMBL6064398 | 0.83 | ACE (0.70) | ACECTSKF2PLGPLAT | |
| SCHEMBL6237696 | 0.72 | ACE (0.58) | ACEANPEPLMNALNPEPERAP2 | |
| SCHEMBL6240311 | 0.72 | ACE (0.58) | ACEANPEPLMNALNPEPERAP2 | |
| SCHEMBL27458051 | 0.72 | ACE (0.58) | ACEANPEPLMNALNPEPERAP2 | |
| SCHEMBL5720686 | 0.71 | ACE (0.52) | ACEANPEPLNPEPERAP2ERAP1 | |
| SCHEMBL5720685 | 0.71 | ACE (0.52) | ACEANPEPLNPEPERAP2ERAP1 | |
| SCHEMBL7267746 | 0.70 | ACE (0.65) | ACEANPEPF2PLGPLAT | |
| SCHEMBL661267 | 0.70 | ACE (0.65) | ACEANPEPF2PLGPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635816-A1 | ENALAPRIL-NITROXYDERIVATIVES DERIVATIVES AND RELATED COMPOUNDS AS ACE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | Nicox S.A. (FR) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004110432-A1 | ENALAPRIL-NITROXYDERIVATIVES DERIVATIVES AND RELATED COMPOUNDS AS ACE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | NICOX S.A. (FR) | 2004-12-23 | — | — | WO | disclosed |