Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.70 |
| ▸ | MME | P08473 | 1/20 | 0.50 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.44 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.44 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.44 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | CPA1 | P15085 | 1/20 | 0.42 |
| ▸ | CPA2 | P48052 | 1/20 | 0.42 |
| ▸ | CPA4 | Q9UI42 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428775 | 0.87 | ACE (0.53) | ACECTSKCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL5870137 | 0.86 | ACE (0.65) | ACEMMECPB2ERAP2ERAP1 | |
| SCHEMBL661267 | 0.86 | ACE (0.65) | ACEMMECPB2ERAP2ERAP1 | |
| SCHEMBL7267746 | 0.86 | ACE (0.65) | ACEMMECPB2ERAP2ERAP1 | |
| SCHEMBL6064947 | 0.83 | ACE (0.49) | ACECPB2ERAP2ERAP1LNPEP | |
| SCHEMBL1133733 | 0.80 | ACE (0.53) | ACEMMECPB2ERAP2ERAP1 | |
| SCHEMBL11113260 | 0.80 | ACE (0.53) | ACEMMECPB2ERAP2ERAP1 | |
| SCHEMBL8436260 | 0.79 | ACE (0.73) | ACEMMEMMP2 | |
| SCHEMBL16566049 | 0.78 | F2 (0.56) | CPB2CTSKF2PLGPLAT | |
| SCHEMBL6237696 | 0.78 | ACE (0.58) | ACEMMEERAP2ERAP1LNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635816-A1 | ENALAPRIL-NITROXYDERIVATIVES DERIVATIVES AND RELATED COMPOUNDS AS ACE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | Nicox S.A. (FR) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004110432-A1 | ENALAPRIL-NITROXYDERIVATIVES DERIVATIVES AND RELATED COMPOUNDS AS ACE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | NICOX S.A. (FR) | 2004-12-23 | — | — | WO | disclosed |