Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | HTR3A | P46098 | 3/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | IDH2 | P48735 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6030680 | 0.81 | HTR3A (0.46) | ADRB1HTR2CHTR3AHTR1DHTR3E | |
| SCHEMBL5560257 | 0.77 | ADRB2 (0.43) | ADRB1SOS1HTR2CHTR3AHTR1D | |
| SCHEMBL4422947 | 0.72 | ADRB2 (0.42) | ADRB1SOS1HTR2CHTR3AHTR1D | |
| SCHEMBL5936578 | 0.70 | CYP1A2 (0.38) | ADRB1SOS1HTR2CADRB2NCF1 | |
| SCHEMBL3409058 | 0.70 | CHRM1 (0.53) | HTR2CHTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL19385666 | 0.70 | ADRB2 (0.55) | ADRB1SOS1HTR2CHTR3AHTR1D | |
| SCHEMBL5936593 | 0.69 | HTR1A (0.46) | ADRB1HTR2CHTR3AADRB2HTR1A | |
| Hydrochloric Acid SCHEMBL19385658 | 0.69 | MAPT (0.55) | ADRB1SOS1HTR2CHTR3AHTR1D | |
| SCHEMBL13179908 | 0.68 | HTR3A (0.58) | ADRB1SOS1HTR2CHTR3AHTR1D | |
| SCHEMBL3414137 | 0.67 | CHRM1 (0.71) | HTR2CHTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622461-B2 | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders | ACADIA PHARMACEUTICALS INC. (US) | 2009-11-24 | — | — | US | disclosed |