SCHEMBL4429951

SCHEMBL4429951

COc1ccc(C(F)(F)F)cc1-c1[c]ccc(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNQ3 O43525 1/20 0.42
KCNQ2 O43526 1/20 0.42
KCNQ4 P56696 1/20 0.42
KCNMA1 Q12791 1/20 0.42
KCNQ5 Q9NR82 1/20 0.42
CYP2C9 P11712 3/20 0.41
MAPT P10636 3/20 0.38
PTGDR2 Q9Y5Y4 3/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
RAB9A P51151 1/20 0.38
CETP P11597 2/20 0.37
DRD4 P21917 1/20 0.36
CASR P41180 2/20 0.36
CYP3A4 P08684 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C19 P33261 1/20 0.36
ALDH1A1 P00352 2/20 0.35
HPGD P15428 2/20 0.35
NPSR1 Q6W5P4 1/20 0.35
KDM4E B2RXH2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4432021 0.86 CETP (0.39) MAPTPTGDR2L3MBTL1RAB9ACETP
SCHEMBL4431199 0.81 NOTUM (0.43) PTGDR2CETP
SCHEMBL4429822 0.81 ACHE (0.43) KCNMA1CYP2C9MAPTL3MBTL1RAB9A
SCHEMBL4439285 0.80 PDE2A (0.39) L3MBTL1ALDH1A1HPGDMEN1KMT2A
SCHEMBL4432401 0.79 AMY1A (0.47) MAPTRAB9AALDH1A1HPGDNPSR1
SCHEMBL4563986 0.78 L3MBTL1 (0.36) MAPTPTGDR2L3MBTL1CYP3A4CYP1A2
SCHEMBL4608507 0.77 HSP90AA1 (0.41) MAPTRAB9AALDH1A1HPGDNPSR1
SCHEMBL9696764 0.77 PDE2A (0.44) MAPTL3MBTL1CETPALDH1A1HPGD
SCHEMBL4426244 0.74 PTGDR2 (0.41) MAPTPTGDR2L3MBTL1RAB9ACASR
SCHEMBL8532282 0.72 CYP1A1 (0.46) CYP2C9MAPTL3MBTL1CYP3A4CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1440976-B1 Modified aminoacids, pharmaceuticals containing these compounds and method for their production BOEHRINGER INGELHEIM PHARMA (DE) 2008-07-23 EP claimed
EP-2121660-A2 FUNGICIDAL AMIDES E. I. Du Pont de Nemours and Company (US) 2009-11-25 EP disclosed
WO-2008091580-A2 FUNGICIDAL AMIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-07-31 WO disclosed