Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 14/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4425054 | 0.82 | GPR52 (0.36) | GPR52EPHX2TNKS | |
| SCHEMBL3166382 | 0.79 | PTGDR2 (0.39) | GPR52ALDH1A1ITGA4ITGB7EPHX2 | |
| SCHEMBL4272168 | 0.77 | EPHX2 (0.37) | EPHX2 | |
| SCHEMBL4415025 | 0.76 | KMT2A (0.39) | ALDH1A1EPHX2 | |
| SCHEMBL4414234 | 0.74 | KMT2A (0.51) | ALDH1A1 | |
| SCHEMBL4413853 | 0.71 | CREBBP (0.49) | ALDH1A1EPHX2 | |
| SCHEMBL4420768 | 0.71 | HDAC1 (0.47) | EPHX2NPC1RAB9A | |
| SCHEMBL12678724 | 0.71 | CASR (0.43) | ALDH1A1EPHX2 | |
| SCHEMBL4426339 | 0.69 | MEN1 (0.49) | NPC1RAB9A | |
| SCHEMBL12678725 | 0.64 | PTGDR2 (0.40) | ALDH1A1ITGA4ITGB7EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |