Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | WDR5 | P61964 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TDP2 | O95551 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44216 | 0.85 | WDR5 (0.52) | LMNAHPGDWDR5 | |
| SCHEMBL13844942 | 0.82 | WDR5 (0.52) | LMNACYP3A4WDR5KDM4ESMN1; SMN2 | |
| SCHEMBL44512 | 0.82 | WDR5 (0.52) | LMNAMAPTWDR5GAAKDM4E | |
| SCHEMBL44258 | 0.80 | CYP19A1 (0.60) | ALDH1A1MAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL44301 | 0.79 | WDR5 (0.66) | ALDH1A1HPGDCYP1A2CYP3A4WDR5 | |
| SCHEMBL44675 | 0.78 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPTHPGDMEN1 | |
| SCHEMBL44576 | 0.77 | WDR5 (0.46) | ALDH1A1MAPTWDR5KDM4ESMN1; SMN2 | |
| SCHEMBL39537 | 0.75 | WDR5 (0.46) | ALDH1A1MAPTHPGDWDR5KDM4E | |
| SCHEMBL7748477 | 0.74 | ALDH1A1 (0.84) | ALDH1A1LMNAMAPTHPGDMEN1 | |
| SCHEMBL38703 | 0.74 | WDR5 (0.44) | ALDH1A1HPGDCYP1A2WDR5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |