Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 10/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.45 |
| ▸ | CFD | P00746 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44512 | 0.85 | WDR5 (0.52) | WDR5LMNANPC1 | |
| SCHEMBL13844942 | 0.85 | WDR5 (0.52) | WDR5LMNACFDPOLBRAB9A | |
| SCHEMBL44653 | 0.85 | ALDH1A1 (0.54) | WDR5LMNAHPGD | |
| SCHEMBL44165 | 0.83 | LMNA (0.48) | WDR5LMNAHPGDAURKA | |
| SCHEMBL44301 | 0.82 | WDR5 (0.66) | WDR5HPGDNPC1RAB9AAURKA | |
| SCHEMBL44576 | 0.80 | WDR5 (0.46) | WDR5TSHRAURKA | |
| SCHEMBL39537 | 0.78 | WDR5 (0.46) | WDR5HPGD | |
| SCHEMBL38703 | 0.77 | WDR5 (0.44) | WDR5HPGDRAB9AAURKA | |
| SCHEMBL44645 | 0.77 | WDR5 (0.51) | WDR5LMNAHPGDSENP1POLB | |
| SCHEMBL44622 | 0.75 | LMNA (0.50) | WDR5LMNAHPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |