Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4371725 | 0.88 | FOLH1 (0.54) | FOLH1MAPTALDH1A1ALOX15TSHR | |
| SCHEMBL22799761 | 0.86 | FOLH1 (0.53) | FOLH1MAPTALOX15KDM4ESLC16A3 | |
| SCHEMBL22800231 | 0.86 | FOLH1 (0.53) | FOLH1MAPTALOX15KDM4ESLC16A3 | |
| SCHEMBL22799766 | 0.86 | FOLH1 (0.53) | FOLH1MAPTALOX15KDM4ESLC16A3 | |
| SCHEMBL7773123 | 0.84 | KDM4E (0.55) | FOLH1MAPTALDH1A1TSHRKMT2A | |
| SCHEMBL13756676 | 0.84 | CYP3A4 (0.44) | FOLH1MAPTALDH1A1TSHRKMT2A | |
| SCHEMBL1648419 | 0.83 | FOLH1 (0.61) | FOLH1MAPTALDH1A1ALOX15TSHR | |
| SCHEMBL89060 | 0.82 | FOLH1 (0.55) | FOLH1MAPTALDH1A1ALOX15TSHR | |
| Benzene SCHEMBL27083018 | 0.82 | FOLH1 (0.55) | FOLH1MAPTALDH1A1ALOX15TSHR | |
| Phthalic Acid SCHEMBL23929048 | 0.82 | ALDH1A1 (0.64) | FOLH1MAPTALDH1A1ALOX15KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118084725-A | 1-Cyano 2-hydroxy compound and preparation method thereof | 南京工业大学 | 2024-05-28 | — | — | CN | claimed |
| CN-118084725-A | 1-Cyano 2-hydroxy compound and preparation method thereof | 南京工业大学 | 2024-05-28 | — | — | CN | disclosed |
| CN-112867722-B | MACROCYCLIC SPIROETHERS (MACROCYCLIC SPIROETHERS) as MCL-1 inhibitors | 苏州亚盛药业有限公司 | 2022-09-23 | — | — | CN | disclosed |
| EP-3459948-B1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2021-11-17 | — | — | EP | disclosed |
| CN-107383002-B | Fluorine-containing triazole pyridine compounds, and preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2021-07-13 | — | — | CN | disclosed |
| CN-112867722-A | MACROCYCLIC SPIROETHERS (MACROCYCLIC SPIROETHERS) as MCL-1 inhibitors | 苏州亚盛药业有限公司 | 2021-05-28 | — | — | CN | disclosed |
| US-10800776-B2 | Fluorine-containing triazolopyridine, and manufacturing method, pharmaceutical composition, and application thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2020-10-13 | — | — | US | disclosed |
| US-20190202827-A1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-07-04 | — | — | US | disclosed |
| EP-3459948-A1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | Shanghai Institute Of Materia Medica Chinese Academy of Sciences (CN) | 2019-03-27 | — | — | EP | disclosed |
| US-8314246-B2 | Catalytic reactions involving alkenes | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-11-20 | — | — | US | disclosed |
| US-20090216025-A1 | Catalytic reactions involving alkenes | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-08-27 | — | — | US | disclosed |
| WO-2007027752-A1 | CATALYTIC REACTIONS INVOLVING ALKENES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2007-03-08 | — | — | WO | disclosed |
| US-5413734-A | 4-cyano-3-fluorophenyl esters | HOFFMANN-LA ROCHE INC. (US) | 1995-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190202827-A1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | GRM2, GRM1, GRIK2 | FOLH1 671/4885MAPT 1028/4885ALDH1A1 3621/4885 |
| US-10800776-B2 | Fluorine-containing triazolopyridine, and manufacturing method, pharmaceutical composition, and application thereof | GRM2, GRM1, GRIK2 | FOLH1 671/4885MAPT 1028/4885ALDH1A1 3621/4885 |
| US-20090216025-A1 | Catalytic reactions involving alkenes | ADH5, ADH1C, ADH1A | FOLH1 2032/4885MAPT 2809/4885ALDH1A1 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.