Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP3 | P15309 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6821850 | 0.72 | DAO (0.48) | ACP3DAOMEN1KMT2A | |
| SCHEMBL4086256 | 0.72 | PNMT (0.58) | ACP3CES2DAOPNMTIDO1 | |
| SCHEMBL13357679 | 0.71 | IDO1 (0.59) | ACP3CES2PNMTIDO1TDO2 | |
| SCHEMBL18952889 | 0.67 | CES2 (0.57) | ACP3CES2PNMTSRD5A2IDO1 | |
| SCHEMBL4437624 | 0.66 | DAO (0.47) | ACP3CES2DAOPNMTSRD5A2 | |
| SCHEMBL5159944 | 0.66 | CES2 (0.69) | ACP3CES2PNMTSRD5A2IDO1 | |
| SCHEMBL6674012 | 0.66 | CES2 (0.69) | ACP3CES2PNMTSRD5A2IDO1 | |
| SCHEMBL7436009 | 0.66 | CES2 (0.55) | ACP3CES2PNMTSRD5A2IDO1 | |
| SCHEMBL5159938 | 0.66 | CES2 (0.69) | ACP3CES2PNMTSRD5A2IDO1 | |
| SCHEMBL15019153 | 0.66 | CES2 (0.55) | ACP3CES2PNMTSRD5A2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |