Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 3/20 | 0.50 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.50 |
| ▸ | OXTR | P30559 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4552418 | 0.82 | P2RX4 (0.45) | USP2NPSR1NPC1RAB9AKMT2A | |
| SCHEMBL4438624 | 0.80 | KDM4E (0.41) | HSD17B10NPC1RAB9AGAAKMT2A | |
| SCHEMBL4438644 | 0.75 | HDAC1 (0.42) | POLBKMT2AHSP90AA1HPGDSMN1; SMN2 | |
| SCHEMBL15056964 | 0.75 | HDAC3 (0.41) | USP2NPSR1RAB9AGAAPOLB | |
| SCHEMBL29493251 | 0.75 | HDAC3 (0.41) | USP2NPSR1RAB9AGAAPOLB | |
| SCHEMBL4553750 | 0.75 | HTT (0.47) | NPSR1KMT2AHDAC3SMN1; SMN2KDM4E | |
| SCHEMBL28245942 | 0.74 | HDAC3 (0.43) | GAAKMT2AHSP90AA1HSP90AB1HDAC3 | |
| Hydrochloric Acid SCHEMBL991577 | 0.73 | HDAC3 (0.42) | GAAKMT2AHSP90AA1HSP90AB1HDAC3 | |
| SCHEMBL4553379 | 0.73 | HSD17B14 (0.43) | HSP90AA1HSP90AB1MGLL | |
| SCHEMBL6168375 | 0.73 | HSD17B3 (0.49) | NPC1RAB9AKMT2AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125741-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008109336-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-09-12 | — | — | WO | disclosed |