Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.37 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553379 | 0.84 | HSD17B14 (0.43) | HSP90AA1HSD17B3TRAP1 | |
| SCHEMBL4438624 | 0.83 | KDM4E (0.41) | KDM4EHSD11B1KMT2AMEN1HPGD | |
| SCHEMBL4552418 | 0.80 | P2RX4 (0.45) | KMT2AMEN1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4430694 | 0.75 | AVPR2 (0.50) | POLBKDM4EKMT2AALDH1A1HPGD | |
| SCHEMBL4430782 | 0.75 | KDM4E (0.43) | KDM4EALDH1A1HPGDSMN1; SMN2TRAP1 | |
| SCHEMBL6168375 | 0.74 | HSD17B3 (0.49) | MAPTKMT2AMEN1HSD17B3 | |
| SCHEMBL29950507 | 0.72 | HDAC3 (0.43) | POLBMAPTKDM4EKMT2AMEN1 | |
| SCHEMBL304994 | 0.72 | HDAC3 (0.43) | POLBMAPTKDM4EKMT2AMEN1 | |
| SCHEMBL27872842 | 0.72 | HDAC3 (0.43) | MAPTKDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL29493251 | 0.71 | HDAC3 (0.41) | POLBMAPTKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125741-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008109336-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-09-12 | — | — | WO | disclosed |