Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.38 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4552418 | 0.88 | P2RX4 (0.45) | NAMPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL4553379 | 0.83 | HSD17B14 (0.43) | HSP90B1TRAP1 | |
| SCHEMBL4438644 | 0.83 | HDAC1 (0.42) | KDM4EHSD11B1KMT2AMEN1TRAP1 | |
| SCHEMBL4430782 | 0.82 | KDM4E (0.43) | KDM4EHSP90B1TRAP1HDAC3HPGD | |
| SCHEMBL4430694 | 0.80 | AVPR2 (0.50) | KDM4EHSD17B10KMT2ANPC1RAB9A | |
| SCHEMBL324380 | 0.76 | P2RX4 (0.42) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL29950507 | 0.76 | HDAC3 (0.43) | KDM4ENAMPTKMT2AMEN1NPC1 | |
| SCHEMBL304994 | 0.76 | HDAC3 (0.43) | KDM4ENAMPTKMT2AMEN1NPC1 | |
| SCHEMBL27872842 | 0.76 | HDAC3 (0.43) | KDM4ENAMPTKMT2AMEN1NPC1 | |
| SCHEMBL305168 | 0.74 | HDAC3 (0.43) | KDM4ENAMPTKMT2AMEN1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125741-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008109336-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-09-12 | — | — | WO | disclosed |