SCHEMBL4430967

SCHEMBL4430967

Cc1[c]cccc1-c1cc(Cl)ccc1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.39
PLA2G7 Q13093 1/20 0.39
CYP3A4 P08684 1/20 0.38
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CASP3 P42574 1/20 0.36
SENP8 Q96LD8 1/20 0.36
SENP7 Q9BQF6 1/20 0.36
SENP6 Q9GZR1 1/20 0.36
S100A4 P26447 2/20 0.35
CHRM1 P11229 1/20 0.34
AGPAT2 O15120 3/20 0.34
MAP4K4 O95819 1/20 0.33
CNR1 P21554 1/20 0.33
JAK2 O60674 2/20 0.32
CRHR1 P34998 1/20 0.32
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4608929 0.86 PTPN1 (0.38) IDO1ALDH1A1S100A4CRHR1HPGD
SCHEMBL4429990 0.81 ELANE (0.38) PLA2G7CYP3A4NPC1KDM4EALDH1A1
SCHEMBL3412249 0.79 IDO1 (0.42) IDO1PLA2G7CYP3A4KDM4ES100A4
SCHEMBL4429896 0.79 PTPRC (0.35) PLA2G7NPC1RAB9AALDH1A1S100A4
SCHEMBL22115865 0.78
SCHEMBL20383160 0.78 CYP3A4 (0.56) IDO1PLA2G7CYP3A4ALDH1A1S100A4
SCHEMBL28816121 0.77 IDO1 (0.38) IDO1PLA2G7CYP3A4NPC1RAB9A
SCHEMBL100932 0.77 TSHR (0.39) IDO1CYP3A4NPC1RAB9AALDH1A1
SCHEMBL4430074 0.76 ALDH1A1 (0.42) PLA2G7NPC1RAB9AKDM4EALDH1A1
SCHEMBL6823830 0.76 PTGS2 (0.42) NPC1RAB9AKDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2121660-A2 FUNGICIDAL AMIDES E. I. Du Pont de Nemours and Company (US) 2009-11-25 EP disclosed
WO-2008091580-A2 FUNGICIDAL AMIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-07-31 WO disclosed
EP-1948649-A2 FUNGICIDAL CARBOXAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2008-07-30 EP disclosed
WO-2007014290-A2 FUNGICIDAL CARBOXAMIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-02-01 WO disclosed