Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428250 | 0.86 | KDM4E (0.54) | KDM4ESMN1; SMN2POLBALDH1A1NPSR1 | |
| SCHEMBL24953219 | 0.82 | KDM4E (0.55) | KDM4ELMNASMN1; SMN2MAPTPOLB | |
| SCHEMBL4431889 | 0.77 | ALDH1A1 (0.49) | KDM4ELMNASMN1; SMN2MAPTPOLB | |
| SCHEMBL4428256 | 0.77 | MDM2 (0.44) | KDM4ELMNAMAPTPOLBALDH1A1 | |
| SCHEMBL1127591 | 0.76 | KDM4E (0.69) | KDM4ELMNASMN1; SMN2MAPTPOLB | |
| SCHEMBL10004025 | 0.74 | ALDH1A1 (0.57) | KDM4ELMNAMAPTPOLBALDH1A1 | |
| SCHEMBL4433040 | 0.73 | MDM2 (0.41) | KDM4ELMNASMN1; SMN2MAPTPOLB | |
| SCHEMBL4429517 | 0.73 | TSHR (0.46) | KDM4ELMNAMAPTPOLBALDH1A1 | |
| SCHEMBL6339142 | 0.72 | ALDH1A1 (0.53) | KDM4ELMNASMN1; SMN2MAPTPOLB | |
| SCHEMBL29522857 | 0.72 | ALDH1A1 (0.53) | KDM4ELMNASMN1; SMN2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |