Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433040 | 0.91 | MDM2 (0.41) | MDM2ALDH1A1KDM4EPOLBTSHR | |
| SCHEMBL4432204 | 0.84 | KDM4E (0.43) | ALDH1A1KDM4ETSHRSLC6A2SLC6A4 | |
| SCHEMBL4432962 | 0.82 | MDM2 (0.42) | MDM2ALDH1A1KDM4EPOLBTSHR | |
| SCHEMBL4429488 | 0.77 | PDE3B (0.47) | MDM2ALDH1A1KDM4EPOLBTSHR | |
| SCHEMBL4430994 | 0.77 | KDM4E (0.53) | MDM2ALDH1A1KDM4EPOLBTSHR | |
| SCHEMBL10004025 | 0.76 | ALDH1A1 (0.57) | MDM2ALDH1A1KDM4EPOLBTSHR | |
| SCHEMBL4429595 | 0.75 | KDM4E (0.40) | KDM4EMAPT | |
| SCHEMBL739464 | 0.74 | TSHR (0.71) | ALDH1A1KDM4ETSHRMAPTLMNA | |
| SCHEMBL11372443 | 0.71 | ALDH1A1 (0.51) | MDM2ALDH1A1KDM4EPOLBTSHR | |
| SCHEMBL4431808 | 0.71 | KDM4E (0.50) | ALDH1A1KDM4EPOLBTSHRPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |