Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428256 | 0.91 | MDM2 (0.44) | MDM2ALDH1A1KDM4EPOLBPDE3B | |
| SCHEMBL4429595 | 0.85 | KDM4E (0.40) | KDM4EMAPTSMN1; SMN2PKMMAPK1 | |
| SCHEMBL4432962 | 0.85 | MDM2 (0.42) | MDM2ALDH1A1KDM4EPOLBPDE3B | |
| SCHEMBL4432204 | 0.75 | KDM4E (0.43) | ALDH1A1KDM4ETSHRSMN1; SMN2SLC6A2 | |
| SCHEMBL4429488 | 0.73 | PDE3B (0.47) | MDM2ALDH1A1KDM4EPOLBPDE3B | |
| SCHEMBL4430994 | 0.73 | KDM4E (0.53) | MDM2ALDH1A1KDM4EPOLBPDE3B | |
| SCHEMBL10004025 | 0.73 | ALDH1A1 (0.57) | MDM2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL4438513 | 0.72 | KDM4E (0.47) | MDM2ALDH1A1KDM4EPDE3BPDE3A | |
| SCHEMBL4439655 | 0.72 | MAPK8 (0.45) | ALDH1A1KDM4EPDE3BPDE3AMAPT | |
| SCHEMBL4438870 | 0.72 | LMNA (0.49) | ALDH1A1KDM4EMAPTLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |