Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 7/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432452 | 0.84 | P2RX7 (0.40) | MEN1LMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL4438527 | 0.83 | CES2 (0.50) | MEN1KMT2ASMN1; SMN2NPSR1POLB | |
| SCHEMBL4431032 | 0.83 | PDE4A (0.45) | MEN1LMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL2304585 | 0.80 | ACP3 (0.56) | TACR1ACP3 | |
| SCHEMBL11103452 | 0.76 | ACP3 (0.55) | MEN1HTTKMT2ASMN1; SMN2MAPT | |
| SCHEMBL4431561 | 0.75 | AKR1C3 (0.48) | TACR1HDAC4 | |
| SCHEMBL4432335 | 0.75 | CES2 (0.41) | MAPTPPARGPPARATACR1ACP3 | |
| SCHEMBL4434672 | 0.74 | PPARG (0.41) | MEN1LMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL4433608 | 0.74 | P2RX7 (0.40) | FFAR1 | |
| SCHEMBL4434628 | 0.74 | AKR1C3 (0.51) | MEN1KMT2AMAPTPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |