Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.43 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3485771 | 0.78 | GPR119 (0.64) | GPR119KDM4EALDH1A1LMNA | |
| SCHEMBL4434868 | 0.76 | GPR119 (0.45) | GPR119PLATPTGS2IKBKBCHUK | |
| SCHEMBL4554614 | 0.68 | GPR119 (0.53) | GPR119 | |
| SCHEMBL3487764 | 0.68 | GPR119 (0.42) | GPR119L3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL10276684 | 0.67 | HCRTR1 (0.41) | ALDH1A1 | |
| SCHEMBL9891735 | 0.66 | CNR2 (0.48) | GPR119PTGS2 | |
| SCHEMBL4435835 | 0.66 | HRH4 (0.33) | GPR119L3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL4499971 | 0.66 | GPR119 (0.46) | GPR119KDM4EALDH1A1LMNA | |
| SCHEMBL532144 | 0.65 | ALDH1A1 (0.69) | GPR119KDM4EALDH1A1LMNA | |
| SCHEMBL14138626 | 0.65 | GPR119 (0.62) | GPR119KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121661-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008085316-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |