Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGT2B7 | P16662 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 7/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MYOC | Q99972 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20987638 | 0.83 | LMNA (0.54) | TRPA1PTGS1CACNA1CMEN1KMT2A | |
| SCHEMBL28001830 | 0.76 | UGT2B7 (0.50) | UGT2B7TRPA1PTGS1CACNA1CMEN1 | |
| SCHEMBL280631 | 0.76 | UGT2B7 (0.50) | UGT2B7TRPA1PTGS1CACNA1CMEN1 | |
| SCHEMBL13711036 | 0.75 | UGT2B7 (0.45) | UGT2B7TRPA1PTGS1CACNA1CMEN1 | |
| SCHEMBL23424906 | 0.72 | TSHR (0.37) | PTGS1MEN1KMT2ALMNAHTT | |
| SCHEMBL6581493 | 0.71 | TDP1 (0.48) | UGT2B7TRPA1PTGS1CACNA1CKMT2A | |
| SCHEMBL20488728 | 0.71 | AKR1C3 (0.49) | UGT2B7TRPA1PTGS1CACNA1CMEN1 | |
| SCHEMBL19414246 | 0.71 | UGT2B7 (0.45) | UGT2B7TRPA1PTGS1CACNA1CMEN1 | |
| SCHEMBL1926385 | 0.71 | AKR1C3 (0.49) | UGT2B7TRPA1PTGS1CACNA1CMEN1 | |
| SCHEMBL5941036 | 0.71 | UGT2B7 (0.45) | UGT2B7TRPA1PTGS1CACNA1CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101668749-A | Novel pyrimidine derivatives 698 | ASTRAZENECA AB | 2010-03-10 | — | — | CN | disclosed |
| EP-2132184-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | AstraZeneca AB (SE) | 2009-12-16 | — | — | EP | disclosed |
| US-20080242663-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | ASTRAZENECA AB (SE) | 2008-10-02 | — | — | US | disclosed |
| WO-2008104754-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | ASTRAZENECA AB (SE) | 2008-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242663-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | EPHB4, EPHB1, NME2 | UGT2B7 755/4885TRPA1 4263/4885PTGS1 1695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.