Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13754339 | 0.79 | TRPA1 (0.40) | TSHRMAPK1L3MBTL1MAPTALDH1A1 | |
| SCHEMBL500563 | 0.76 | TSHR (0.56) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL20987638 | 0.75 | LMNA (0.54) | MAPK1MAPTALDH1A1HTTMEN1 | |
| SCHEMBL6546683 | 0.73 | ATM (0.48) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL4432089 | 0.72 | UGT2B7 (0.42) | TSHRMAPK1TDP1MAPTALDH1A1 | |
| SCHEMBL444227 | 0.69 | TP53 (0.56) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL11662131 | 0.67 | ESR1 (0.70) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL13344096 | 0.67 | ESR1 (0.45) | MAPK1L3MBTL1MAPTALDH1A1NPC1 | |
| SCHEMBL24114033 | 0.67 | TSHR (0.47) | TSHRMAPK1ATMTDP1L3MBTL1 | |
| SCHEMBL8258347 | 0.66 | AOC1 (0.36) | TSHRCYP3A4RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021099803-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF ACUTE INTERMITTENT PORPHYRIA | VESTLANDETS INNOVASJONSSELSKAP AS (NO) | 2021-05-27 | — | — | WO | disclosed |